What is an RTG?

RTG stands for Research Training Group. These are established to provide PhD students with a focused, high-quality research environment, centered around an overarching research theme. The aim of an RTG is to promote early-career researchers by fostering both their academic and professional development in a collaborative, interdisciplinary setting.

RTG 2408

In 2018, RTG 2408 titled "Maladaptive Processes at Physiological Barriers in Chronic Diseases" was established at the OvGU Magdeburg. The qualification program does not only foster basic research by funding and supervising PhD projects but also supports Clinician Scientists’ (i.e., doctors who are engaged in research) and medical students’ projects. By bringing together PhD students, medical students and physicians RTG aims to promote various translational approaches, making it easier to convert basic research discoveries into clinical therapies, ultimately improving patient outcomes.

Research scope

Chronic diseases represent a significant health threat, placing an increasing strain on healthcare systems. A central issue in many chronic conditions is cellular maladaptation and impaired communication at physiological barriers (e.g. skin, intestine, lung etc.), which are defined by specialized cells like endothelial and epithelial cells. Dysfunction in these barriers can create a disease-promoting environment, characterized by a specific secretome and the activation of local and inflammatory cells. However, our understanding of the molecular mechanisms behind these maladaptive changes at physiological barriers remains limited.

The RTG 2408 aims to unravel these disease-defining maladaptive processes at endothelial and epithelial barriers.

A broad scope of research topics enables knowledge exchange and the combination of experimental models (e.g., animal models, organoids, coculture systems) and advanced technical methods (e.g., high-resolution 3D imaging, intravital 2-photon microscopy, mass spectrometry). This interdisciplinary approach adds significant value for early-career researchers. By exposing young scientists to cutting-edge methodologies and relevant research areas, RTG 2408 prepares them for independent research careers.

Qualification program

In addition to scientific research, RTG 2408 provides a structured training environment for early-career researchers. With a focus on collaboration, mentoring, and professional development, young scientists gain exposure to state-of-the-art methodologies, while clinicians and medical students contribute to a dynamic, translational research environment. In particular, events such as colloquia, summer school, career days, internal retreats and joint retreats with other RTGs promote active involvement and development of crucial soft skills for early scientific independence.

Magdeburg and surroundings

Magdeburg, the capital of the state of Saxony-Anhalt, is a city rich in history and innovation. Situated on the banks of the Elbe River, it boasts a blend of historical landmarks and modern developments. The iconic Magdeburg Cathedral, the oldest Gothic cathedral in Germany, and the strikingly modern Green Citadel designed by Friedensreich Hundertwasser, are just two of the city's architectural highlights.

Beyond its cultural heritage, Magdeburg is a hub for research and education, home to the Otto von Guericke University, known for its cutting-edge research in science, engineering, and medicine. The city’s close ties to research make it an ideal location for scientific symposia.

Surrounded by scenic parks, nature reserves, and the picturesque Harz Mountains, Magdeburg offers plenty of opportunities for outdoor activities, making it a great place to explore both urban and natural landscapes. Its rich history, vibrant culture, and commitment to innovation provide an inspiring environment for academic exchange.

History of Magdeburg

Magdeburg was officially founded in 805 AD as a trading post under the reign of Charlemagne. Its strategic location along the Elbe River made it a vital center for commerce and military operations in the early medieval period. In 968 AD, Magdeburg gained prominence when Emperor Otto I, known as Otto the Great, established the Archbishopric of Magdeburg, making the city an important religious and political center of the Holy Roman Empire. Otto I also chose Magdeburg as his preferred residence and was later buried in the city's cathedral.

Throughout the middle Ages, Magdeburg flourished as a member of the Hanseatic League, becoming a significant hub for trade and culture. The city played a key role in the Protestant Reformation but was heavily impacted during the Thirty Years' War, culminating in the devastating siege and destruction of the city in 1631, known as the "Sack of Magdeburg."

Despite its turbulent history, including significant damage during World War II, Magdeburg has continuously rebuilt itself. Today, it stands as a city rich in history, with a unique blend of medieval landmarks like the Magdeburg Cathedral and modern architecture.